by Justine Donzel on Oct 4, 2024 1:59:29 PM
Mathieu Reuther, a Research Assistant at AdhexPharma wrote and published a research study as part of his professional thesis in the "Journal of Drug Delivery Science and Technology".
You can read the article for free (until November 14th 2024).
The article entitled "Development of a new method for analyzing the behavior of rapidly dissolving films in contact with liquids" highlights :
- New analytical method for determining the disintegration time of oral thin film by goniometry.
- Better repeatability than the current method adapted from Pharmacopoeia tablet monography.
- Additional information on the wettability properties and film behavior in contact with liquids to optimize film formulation.
[An Oral Thin Film (OTF) is a drug delivery system that consists of a thin layer of mainly hydrophilic polymer designed to be rapidly disintegrated or dissolved in the mouth upon contact with the saliva without drinking water or chewing it. It allows a fast release of active pharmaceutical ingredients (API). A wide range of polymers can be used in OTFs. They are generally hydrophilic and water-soluble, but can also be more hydrophobic and water-insoluble. OTFs were introduced into the European Pharmacopoeia (Ph.Eur.) with supplement in April 2012 and are subordinated to the oromucosal preparations. The disintegration time of an OTF is a critical quality attribute, so it is essential to know and understand the behavior of the film in contact with water or aqueous liquids. Disintegration time is the time at which the film has totally break down when brought into contact with water...]
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